High 3 grants in regenerative drugs: August 2022

High 3 grants in regenerative drugs: August 2022

This month’s high grants in regenerative drugs, sourced from Dimensions, embody tasks on: affected person particular Alzheimer’s Illness fashions, a plant-derived biomaterial platform for culturing human stem cells and an investigation into the transformation of bone therapeutic mechanomics with age.

Try this month’s high grants in regenerative drugs:

 

Affected person particular Alzheimer’s Illness fashions

The non-genetic causes of Alzheimer’s illness (AD) should not effectively understood as animal fashions are dissimilar to the human mind and present approaches to culturing mind cells don’t present an correct illustration of AD. To beat these challenges, researchers need to stem cells. Using stem cells from AD sufferers can present mind tissue fashions with the identical genetic make-up as the unique human supply. This undertaking goals to design a cell tradition surroundings just like pure mind tissues to straight observe the unfold of AD to higher perceive the underlying mechanisms of the illness.

Funding quantity: US$28,000

Funding interval:  1 September 2022 – 31 August 2025

Funder: Canadian Institutes of Well being Analysis (CIHR)

Analysis group: Dalhousie College (Halifax, Canada)

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The transformation of bone therapeutic mechanomics with age

The method of bone therapeutic is mechano-sensitive, due to this fact mechanical stimuli can both encourage or hinder fracture therapeutic. This undertaking will make use of a multi-scale, multi-disciplinary method to unravel the mechanisms underling the mechanobiology of bone therapeutic and examine how this mechano-sensitive therapeutic course of is compromised with age. This analysis will spatially map the native mechanical surroundings, the molecular profile of single cells and the native nanostructure inside the fracture callus. The analysis will quantify how particular person cells and subcellular parts reply to mechanical stimulation to construct bone. It would additionally allow investigation of the potential pathways by which the formation of bone nanostructure is influenced by mechanical stimuli. General, the insights gained from this investigation will goal to supply novel therapeutic targets and new methods to advertise bone restore.

Funding quantity: US$212,000

Funding interval:  1 September 2022 – 31 August 2024

Funder: European Fee (EC)

Analysis group: ETH Zurich (Switzerland)

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A chemically outlined plant-derived biomaterial platform for culturing human stem cells

This analysis goals to develop a decellularized plant-based biomaterial to be utilized within the tradition of human stem cells. Plant leaf manufacturing is scalable and sustainable, and this, together with the range of morphology and size and their biocompatibility make them a probably helpful biomaterial for human stem cell manufacturing. This undertaking will characterize plant-derived biomaterials and develop methodology to coat them in an artificial polymer to switch the floor and make the ensuing cell-biomaterial conducive to human cell tradition. With this information, the impression of floor topography and the adaptable floor chemistry on mobile alignment and differentiation could also be additional investigated.

Funding quantity: US$565,000

Funding interval: 1 September 2022 – 31 August 2025

Funder: Directorate for Mathematical & Bodily Sciences (NSF MPS)

Analysis group: College of Wisconsin – Madison (USA)

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